732型阳离子交换树脂分离富集-分光光度法测定钼精矿中微量铜的研究

根据亚铜离子和亚铜灵反应生成黄色配合物在457nm处吸收光的性质,以732型阳离子交换树脂作为吸附剂,建立了离子交换树脂柱分离富集-分光光度法测定钼精矿中微量铜的方法.上柱液在pH值为3～4范围内,以1.4mL/min的流速通过树脂吸附柱,用10mL浓度为3.0mol/L的盐酸进行洗脱,可以消除大部分共存离子的干扰.本方法的检出限为0.75μg/L.该方法应用于钼精矿中微量铜的测定,精密度RSD为4.5%,加标回收率在96.0～108.0%之间;测定结果与原子吸收法基本一致.     

Human metabolic individuality in biomedical and pharmaceutical research

Genome-wide association studies (GWAS) have identified many risk loci for complex diseases, but effect sizes are typically small and information on the underlying biological processes is often lacking. Associations with metabolic traits as functional intermediates can overcome these problems and potentially inform individualized therapy. Here we report a comprehensive analysis of genotype-dependent metabolic phenotypes using a GWAS with non-targeted metabolomics. We identified 37 genetic loci associated with blood metabolite concentrations, of which 25 show effect sizes that are unusually high for GWAS and account for 10-60% differences in metabolite levels per allele copy. Our associations provide new functional insights for many disease-related associations that have been reported in previous studies, including those for cardiovascular and kidney disorders, type 2 diabetes, cancer, gout, venous thromboembolism and Crohn's disease. The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research.     

我国湿地保护立法研究

湿地被称为“地球之肾”，是地球三大生态系统之一，在促进生态文明建设、构建和谐社会中具有重要作用．然而，近年来我国湿地破坏严重，其原因主要是我国湿地保护法律制度的不健全．我国湿地保护立法缺少中央立法、湿地内涵与外延不明确等，应借鉴发达国家经验提出相关完善建议．     

汾河流域降水量及蒸发量的空间变异性分析研究

借助于地质统计学方法对汾河流域的多年平均降雨量和蒸发量的空间变异性进行了分析,揭示了多年平均降水量和蒸发量的空间变异特征,并应用Kriging方法进行空间插值.分析结果表明,汾河流域多年平均降水量和蒸发量在不同的分割距离范围内有不同的空间相关性,多年平均降水量具有比较明显的地带性,蒸发量分布变化地带性不强.     

WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway

Toll-like receptors (TLRs) act as sensors of microbial components and elicit innate immune responses. All TLR signaling pathways activate the nuclear factor-kappaB (NF-κB), which controls the expression of inflammatory cytokine genes. Transforming growth factor-β-activated kinase 1 (TAK1) is a serine/threonine protein kinase that is critically involved in the activation of NF-κB by tumor necrosis factor (TNFα), interleukin-1β (IL-1β) and TLR ligands. In this study, we identified a novel protein, WD40 domain repeat protein 34 (WDR34) as a TAK1-interacting protein in yeast two-hybrid screens. WDR34 interacted with TAK1, TAK1-binding protein 2 (TAB2), TAK1-binding protein 3 (TAB3) and tumor necrosis factor receptor-associated factor 6 (TRAF6) in overexpression and under physiological conditions. Overexpression of WDR34 inhibited IL-1β-, polyI:C- and lipopolysaccharide (LPS)-induced but not TNFα-induced NF-κB activation, whereas knockdown of WDR34 by a RNA-interference construct potentiated NF-κB activation by these ligands. Our findings suggest that WDR34 is a TAK1-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-κB activation pathway. D. Gao and R. Wang contributed equally to this work.     

Removable ears of 1-extendable graphs

<正> Carvalho,Lucchesi and Murty proved that any 1-extendable graph G different from K_2and C_(2n)has at least Δ(G)edge-disjoint removable ears,and any brick G distinct from K_4 and■hasat least Δ(G)-2 removable edges,where Δ(G)denotes the maximum degree of G.In this paper,weimprove the lower bounds for numbers of removable ears and removable edges of 1-extendable graphs.It is proved that any 1-extendable graph G different from K_2 and C_(2n)has at least χ′(G)edge-disjointremovable ears,and any brick G distinct from K_4 and■has at least χ′(G)-2 removable edges,whereχ′(G)denotes the edge-chromatic number of G.     

花岗岩型铀矿床的三种成矿模式及其找矿意义

花岗岩型铀矿床的成因是多种多样的,作者认为可用“演化成矿”,“活化成矿”及“演化和活化混合成矿”三种成因模式概括华南花岗岩型铀矿床的成矿过程.对三种模式的成矿机理及找矿意义的研究表明,与不同成因系列产铀花岗岩有关的铀矿床成因专属性存在着差别.与改造型产铀花岗岩有关的铀矿床成因类型较多,上述三种成因模式均可见到,而与同熔型产铀花岗岩有关的铀矿床则以“演化成矿”为主.属不同成矿模式的铀矿床其铀富集机理和成矿过程也不尽相同,故其找矿判别标志也有所差异.     

陶瓷强度的统计方法

陶瓷作为结构材料，强度离散及尺寸效应是所面临的主要问题之一。围绕这一问题，归纳和分析了当前应用统计学进行处理的主要理论和方法．对统计模型的建立、分布函数的参数估计、强度的尺寸效应，以及由材料试验获取强度分布函数的参数所存在的问题等，作了比较细致的讨论，提出了几个新的看法。     

一种新型的矿井通信设备—诱导电话

本文介绍一种新型的矿井通信设备——诱导电话,给出了设备的设计思想、指标、框图,及其部分具体电路和数据。